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The increased incidence of DCIS has been found in randomized controlled trials and service screening to be at least partly balanced by a later reduction in invasive cancer incidence [ 7, 14].
The ability of the DHI to measure meaningful or clinically important change, has scarcely been examined [ 12], and variable results regarding the ability of the DHI to discriminate between treatment and control groups, have been found in randomized controlled trials [ 17- 25].
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This has been found in a randomized trial involving a mixed ICU population [ 14].
A significant reduction of bacteremia, candidemia, ventilator-associated pneumonia, respiratory tract and rectal colonization have been found in multicenter, randomized studies.
Such an alcohol-related increase in insulin sensitivity has been found in observational studies as well as in randomized controlled trials (Davies et al. 2002; Kiechl et al. 1996; Lazarus et al. 1997; Mayer et al. 1993; Sierksma et al. 2004).
15 The strongest evidence for doxycycline's relatively good tolerability is found in three randomized, double-blinded trials.
A similar lack of evidence for a prophylaxis antifungal strategy in at-risk ICU patients was found in a randomized, placebo-controlled study of caspofungin [ 24].
No significant peaks were found in 50 randomized sequences tested (see Fig. 3B), suggesting that significant peaks rarely occur by chance with the selected settings.
13 In contrast to our cohort analysis, no in pre- and postoperative difference in CRP and in postoperative hospital stay between the 2 groups was found in our randomized trial.
Further evidence to support the potential for vitamin D to resolve oxidative damage may be found in a randomized clinical trial in patients with colorectal adenoma where a 25% reduction in 8-OHdG following vitamin D supplementation was reported [ 45].
However, an increase in serotype 19A pneumococci was found in a randomized controlled study of nasopharyngeal carriage among vaccinated children compared with unvaccinated controls before national implementation of PVC-7 (27 ).
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