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In agreement with our results, a dramatic down regulation in the expression of pfn isoforms has been found in invasive breast cancer cells compared with its non tumorigenic counterparts using gene expression profiling [30].
In fact, although a low expression of E-cadherin has been found in invasive carcinomas without metastases, high E-cadherin levels have been observed in nodal metastases as compared with their primary tumour (Beavon, 2000; Kowalski et al, 2003; Harigopal et al, 2005; Jeschke, 2007).
Of note among the miRNAs that have recently been identified is the strong upregulation of miR-135b which has been found in invasive mammary BALB-neuT carcinomas; acting on its targets, midline 1 (MID1) and mitochondrial carrier homolog 2 (MTCH2), it regulates CSC stemness in vitro and cancer cell metastatization in vivo [ 49].
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A loss of cellular adhesion genes was found in invasive tumours, which may in turn be related to invasion and metastasis.
When P-moesin staining was studied, similar patterns of sub-cellular distribution were found in invasive cancers (focal vs. intense staining; membrane vs. membrane/cytoplasmic vs. cytoplasmic, Fig. 12), but there was no significant association with either ER or lymph node status (Table 1).
Invadopodia are similar, but are found in invasive cancer cells.
Also, pY397FAK was found in invasive ovarian carcinomas, but not in normal ovarian epithelium [ 18].
A further significant increase in immunoreactivity was found in invasive tumours compared with DCIS (P<0.02).
No HPV DNA sequences were found in invasive breast carcinoma [ 78, 79].
Elevated production and levels of IL-1 system components are found in invasive breast cancer (Apte and Voronov, 2002).
φ3 bacteriophage and human specificity genes (chp, sak, scn) were found in invasive human but not pig isolates.
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