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Such a cost-saving has also been found in critically ill patients.
Lower levels of adiponectin have been found in critically ill patients [ 58, 63- 65].
Both low and high VEGF concentrations have been found in critically ill patients, and its significance is not completely understood [ 21, 44, 45].
Low levels of adiponectin have been found in critically ill patients, although data are limited in human subjects at this stage.
Groeger and colleagues found a correlation between hospital length of stay prior to ICU admission and mortality in critically ill cancer patients [ 33, 45, 46], and this has also been found in critically ill patients as a whole [ 47].
Increased plasma levels of circulating natriuretic peptides, atrial natriuretic peptide, N-terminal pro-atrial natriuretic peptide, brain natriuretic peptide and its N-terminal moiety N-terminal pro-brain natriuretic peptide have also been found in critically ill patients.
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Interestingly, hyperchloremic acidosis antagonized by hypoalbuminemic alkalosis was found in critically ill patients with and without liver disease.
However, one of the most intensively studied perturbations of TH feedback regulation is found in critically ill patients and has been described as "low T3 syndrome", "nonthyroidal illness" or "euthyroid-sick syndrome" [9], [10].
Autonomic dysfunction in general may also increase mortality, as was found in critically ill patients [ 30].
Only a modest mucosal atrophy (i.e. = 10%% decrease in thickness) was found in critically ill humans [ 5].
Whether the bioavailability of LMWHs decreases during an acute phase response, as it can be found in critically ill patients, is unknown [ 12, 26].
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