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Evidence for persistent CMV genomes and antigens exists in many tissues after initial infection, and CMV has been found in circulating mononuclear cells and in polymorphonuclear neutrophils [ 84].
As miR455 has been found in circulating blood, the development of noninvasive prenatal tests enabling early diagnosis of preeclampsia may be possible.
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CNPs were found in circulating erythrocytes.
No significant changes were found in circulating levels of calcium, inorganic phosphate, or PTH (Figure S4), measured as indicated in the Supplementary Methods (Text S1) section.
An upregulated MMP-9 was found in circulating lymphocytes [ 66].
However, significantly reduced miR-126 levels were found in circulating microparticles from CAD patients with T2DM [ 88].
All of these features were found in circulating monocytes isolated from patients with chronic lymphocytic leukemia (CLL) [ 86].
Remarkably, despite the fact that no detectable VN titers were found in circulating blood, the animals vaccinated by intranasal route with BoHV-1ΔgEβgal virus were protected against challenge.
Conceptually, this fits with the idea that TICs are invasive [ 12], and as such, they are found in circulating tumor cells from patients [ 56].
One of the best characterized is xanthine oxidase, which is present in the cytosol of many tissues but also can be found in circulating blood and bound to glycosaminoglyan sites in the arterial wall [ 19].
The broader relevance of this observation is unclear, since no differences were found in circulating FIAF levels of conventional C3H mice fed a Western or high-fat diet as compared with germ-free mice (Fleissner et al. 2010).
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