Overall, no significant differences were found for primary outcomes (figure 3).
Overall, no significant differences were found for primary outcomes which varied across studies.
A maximum variation of up-regulated genes at 96 h was found for "primary metabolism", "transport" and "stress defense and response".
Significant univariate associations were found for primary tumour site, size of dominant lesion <5 cm and concurrent use of 5-FU chemotherapy (Table 3 and Supplementary table online).
After adjustment for differences in age, sex, and type of fixation of the prosthesis, no difference in risk of revision was found for primary THAs performed due to pediatric hip diseases and those performed due to primary OA.
Although the expected error of such measurements (based on the sampling statistics) is low (5 10%), the results from different studies disagreed widely, covering a range of almost a factor 2 (48 000 per cubic millimeter, Beaulieu 1993; 77 000 per cubic millimeter, Keller and Carlson 1999, for rat primary somatosensory cortex; similar disagreements can be found for primary visual cortex).
No differences between groups were found for primary end points – frequent wheeze (OR 1.51, 95% CI 0.83 to 2.76, p=0.17), speech-limiting wheeze (OR 0.70, 95% CI 0.32 to 1.48, p=0.35), sleep disturbed because of wheezing (OR 1.17, 95% CI 0.64 to 2.13, p=0.61) or for any secondary end points.
Considerably higher catalytic rates have been found for the primary detoxification enzymes in the bacteria, with kcat values typically in the range of several to several thousand turnovers per second (Table 1), compared with one turnover per thousand seconds or slower for the insect enzymes (where kinetic data are available; Table 2).
No such correlation has been found for miR-125b expression in primary tumor tissue so far.
We also did not look specifically to see whether a changed primary outcome was the one with a statistically significant finding, just whether a statistically significant finding was found for any primary outcome for the study.
