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Using a V-shaped-based design approach, a top-down VHDL-AMS-based modeling has been first achieved with behavioral, structural behavioral, and component models, which include a MEMS-based pneumatic microactuator.

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By taking advantage of the modified AuNPs and the enhanced electrochemical performance of the nanoelectrode, a wide dynamic linear range from 2.0×10−8 M to 5.6×10−6 M with a low detection limit of 1.0×10−8 M (S/N=3), as well as good selectivity for dopamine, were first achieved with the Nafion-modified Au/GCNE.

Shape-memory was first achieved with other materials.

Geometry optimization of each cholesterol-lipid complex was first achieved with the Polak-Ribiere algorithm.

Although FLP was the first site-specific recombinase used in genetic engineering of higher eukaryotes, successful site-specific recombination in mammalian cells and mice was first achieved with and mostly involved Cre, largely due to its highly efficient recombination activity in mammals.

Multiplayer gaming, which is now integral to the first-person shooter genre, was first achieved successfully on a large scale with Doom.

Intracellular applications of engineered repeat proteins were first successfully achieved with designed ankyrin repeat proteins (DARPins), [ 20] and TPR [ 21].

It was the Boers, however, who were first to achieve diplomatic successes with Lobengula.

The first results are presented that were achieved with GAPatrol, an evolutionary multi agent-based simulation tool devised to assist police managers in the design of effective police patrol route strategies.

In the present study, the maximum debris removal in the apical third was achieved with the EndoVac followed by the tip-vented and side-vented irrigation systems.

The calculated responsivity was estimated to be 5 mA W−1, comparable (10 times higher) to the value that has been achieved with the first prototypes of those 2D materials [115, 116].

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