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Fluoroquinolones have been the most successful antibacterial agents targeted to gyrase, but these compounds have been extensively explored both in terms of improving spectrum and potency, and overcoming bacterial resistance, and we may have reached the limits of what these compounds can provide.
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She's extensively explored both roles through clothes ever since, with both Marilyn Monroe and Catholic iconography being key inspirations behind her expansive back catalogue of looks, from 1950s glamour girl (Material Girl) to penitent sinner (Like a Prayer) and spiritual entity (Ray of Light).
As an example, T1D is a disease in which the underlying autoimmune pathogenesis has been extensively explored in both mice and humans.
The contribution of the LRR and WD40 protein-protein interaction domains to LRRK2 function has not been extensively explored, yet either or both of these may contribute to the proper formation of LRRK2-containing complexes.
SnO2 has been extensively explored as a potential anode material for both Li-ion (LIBs) and Na-ion batteries (SIBs).
Electrospun nanofibers have been extensively explored as tissue engineering scaffolds for repairing both the central and peripheral nervous systems.
Ionophores and ion channels, both synthetic and biological, have been extensively explored and exploited.
In regenerative medicine and tissue engineering, both naturally derived and synthetic materials have been extensively explored and provided their respective advantages [4].
Despite this, the reasons underlying both successful and false predictions have not been extensively explored.
Although these issues have been extensively explored, some uncertainty remains.
These kinds of settings have not been extensively explored.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com