Consequently, concerns have been expressed that rigid fixation, such as that seen with static anterior plating, may result in graft stress shielding, thereby reducing the mechanical load that is necessary for the success of graft healing [ 9].
If concern is expressed that implementing such a program could end up increasing the exposure to lawsuits because any deficiency or oversight in meeting self-imposed safety requirements could provide the basis for a negligence lawsuit, help the club or school board understand that such fear shouldn't be an impediment to implementation.
Concerns have been expressed, however, that such large-scale breeding programmes based on one specific factor (in this case, PrP genotype) could have detrimental side-effects on sheep performance.
One difficulty in RNA-Seq transcriptome research is that certain genes can be expressed at such low levels that the total number of cDNA sequences obtained (sequencing depth) can be insufficient to detect them [ 24].
Furthermore, mRNA data obtained from purified primary L cells suggest that Tas1R1/Tas1R3, CasR and GPRC6A are expressed at such low levels that one might question their functional significance (Table 3).
This suggested that if the DAOA protein exists at all, it is expressed at such low levels that any physiological role is called into question [ 36].
While further studies are required to understand the significance of the G72/30 locus to schizophrenia, we propose that if native G72 protein exists at all, it is expressed at such low levels that any physiological role is called in to question.
While the pathogenic role of chitinases/CLPs in (dys)regulation of inflammation in CF airways remains poorly understood, observations in lungs from Scnn1b-transgenic mice demonstrate that some proteins of the chitinase/CLP family, such as Ym1 and Ym2, are expressed at such high levels that they precipitate and form sharp crystals often greater than 100 μm in size [54].
10, 11 Additional homologs have not been identified or are expressed at such low levels that their roles have not been established.
The fifth is Arl5 with there being two clear Arl5 paralogues in humans, Arl5a and Arl5b, with a third related gene ARL5C being expressed at such low levels that it may be a pseudogene.
