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This substrate specificity has been exploited to engineer biosensors able to detect even minimal amounts of different phenolic compounds.
Such systems have been exploited to engineer genetically encoded redox sensors to detect dynamic oxidative changes within a cellular environment.
This featured article describes and illustrates different photochemical processes, which have been exploited to engineer new probes for the detection and the site-specific production of ROS.
The diversity of biological function, ligand binding, conformational changes and structural adaptability of the periplasmic binding protein superfamily have been exploited to engineer biosensors, allosteric control elements, biologically active receptors and enzymes using a combination of techniques, including computational design.
The versatility afforded by the process has been exploited to engineer a range of variously oriented, interconnected and graded structures within the composite with a view to maximising conductivity whilst minimising the volume fraction of non-emitting metallic phase.
The ability of a cell to repair a DSB generated by Cas9 through HDR-mediated incorporation of exogenous DNA templates has recently been exploited to engineer several modifications to endogenous loci, such as novel knock-in alleles, point mutations and fluorescent tags, among others.
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In recent years, the knowledge acquired in phage display technology was exploited to engineer phages as vehicles for receptor-mediated gene delivery.
An unexpectedly high tolerance to mutation in the active sites of DNA polymerases is being exploited to engineer polymerases to incorporate artificial nucleotides or to display other, nonnatural activities.
Reovirus reverse genetics has been used to introduce mutations into viral capsid and nonstructural components to study viral protein-structure activity relationships and can be exploited to engineer recombinant reoviruses for vaccine and oncolytic applications.
Cell-free protein synthesis is applied to expanding protein and nucleic acid biochemistry and enabling novel assay formats, while programmable DNA-circuits can be exploited to engineer sensitive detection methods.
Traditional agricultural practices can partly enhance the nutritional value of plant foods, but the advances in the 'omics' technologies are rapidly being exploited to engineer crops with enhanced key nutrients.
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CEO of Professional Science Editing for Scientists @ prosciediting.com