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This is illustrated by the case of Ilyanassa, where D cell division asymmetry has been exapted to functionally replace a primitive head-patterning signal.
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Some transposable elements have been exapted to modulate gene regulatory networks (reviewed by [ 40]).
This interaction appears to have been exapted to utilize the HEPN domain as a substrate-binding or regulatory domain for the MNTs.
In their active role, TEs can be exapted to create new genes or functional sequences (also referred to as molecular domestication).
Given, however, that translation is a highly conserved and ancient process [ 35], it is more likely that protein functions would originate within the translation network and be exapted to another more recent network rather than the other way around.
Later, they became exapted for flight, and in tail feathers, they were exapted to play a role in aiding the bird's maneuverability as it flies (Matyjasiak et al. 2004).
Distal-less seems to have performed more ancient and basic jobs before being exapted to speckle the wings of butterflies (see True and Carroll 2002 for a review of this example).
The next most frequent TE super-family, which is exapted to generate novel LSGs, are DNA/MuDR transposons with 48 exapted TE fragments (23.53% of total TE exaptations).
For instance it has been shown that many transposon-derived sequences have been exapted into functional roles such as regulatory elements controlling gene expression [ 5] and contributing to proteome diversity through introduction of cryptic splice sites and exonization [ 6].
Therefore, some of these new lncRNAs may have been exapted for new functions in E. multilocularis.
However, several cases have been reported where the acquired host gene seems to have been exapted [ 8] for a function in virus reproduction that was not obviously related to the original one.
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