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The high-dose tigecycline regimen that Cunha proposes for multidrug-resistant organisms has never, to our knowledge, been evaluated in randomized trials or even in large prospective evaluations.
Surprisingly few antibiotic schedules prescribed for the treatment of CLD have been evaluated in randomized double-blind placebo-controlled clinical trials (RCTs).
Lung cancer screening with low dose computed tomography (CT) has not yet been evaluated in randomized clinical trials, although several are underway.
The gemcitabine-based combinations and treatments recommended in the metastatic setting (eg, fluorouracil, leucovorin, irinotecan, and oxaliplatin and gemcitabine plus nanoparticle albumin-bound paclitaxel) have not been evaluated in randomized controlled trials involving locally advanced, unresectable pancreatic cancer.
Many of these interventions have been evaluated in randomized controlled trials and systematic reviews.
Paclitaxel is an active agent for cervical cancer and has been evaluated in randomized trial.
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The following evaluable patient populations are defined for selected endpoints: Tumor response will be evaluated in randomized patients with measurable disease at baseline, CA 19 9 response will be evaluated in randomized patients with available CA 19 9 assessment at baseline.
The frequency of reporting of 11 basic elements of design and analysis was evaluated in randomized clinical trials (RCT), nonrandomized clinical trials (NRCT), and retrospective cohorts (RC) from JPS by consensus of 2 assessors.
2,4-D, Puma super, 2,4-D + Puma super at 1.25 L ha−1 each, Affinity at 2 kg ha−1 and weedy check were evaluated in randomized complete block design with split plot arrangement replicated four times.
All 40 images (20 processed half-time images and 20 standard images) were evaluated in randomized order.
Effects on Kessler-6 were more beneficial for girls least likely to move compared with girls most likely to move (-0.62 vs. 0.02; interaction; P = 0.03).Evidence of individualized treatment selection differed by child gender and outcome and should be evaluated in randomized trial reports, especially when heterogeneous treatment effects are likely and nonadherence is common.
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