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These vaccines produced by well controlled and reproducible processes have also been evaluated in human clinical trials.
This article focuses on the current available examples of instances where toxicogenomic data has been evaluated in human health risk assessment (e.g., acetochlor and arsenicals) which have been limited to the application of toxicogenomic data to inform mechanism of action.
To the best of our knowledge, these effects of PPAR-γ agonists have not been evaluated in human 18F-FDG PET/CT images so far.
11C-TMSX has been evaluated in human brain studies in not only healthy human controls [4]-[7[4]-[7also in drug-naïve Parkinson's disease patients before and after therapy [8].
Furthermore, in vitro toxicity of silver nanoparticles at non-cytotoxic doses has been evaluated in human hepatoma cell line and HepG2 by various assays, wherein it was revealed that silver nanoparticles accelerate cell proliferation at low doses (<0.5 mg/L) due to stimulation of genes associated with cell cycle progression.
Further experiments using PfMSP1-based vaccines with GMP level, which have been evaluated in human clinical trials, would be needed to investigate the susceptibility of Pb-PfMSP119 to anti-PfMSP119 responses.
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However, the effect of binge drinking on neuroplasticity has not been evaluated in humans.
The cytoprotective effect of hepatovenous back-perfusion has not been evaluated in humans.
A formalin-inactivated investigational RVFV vaccine, TSI-GSD-200, has previously been evaluated in humans and found to be safe but poorly immunogenic, requiring three primary immunizations and a booster dose to generate and maintain neutralizing antibody responses15.
We have made significant progress over the last cycle of this CCNE competing renewal grant including the development of photoacoustic molecular imaging hardware that has already been evaluated in humans.
Although many of these agents have been evaluated in humans, by far the most extensive clinical literature has described use of the 68Ga and 177Lu agents.
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