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Both sorafenib and erlotinib have been evaluated as single agents for the treatment of patients with biliary cancers.
Paclitaxel, gemcitabine and oxaliplatin have been evaluated as single agents, and the combinations paclitaxel and gemcitabine (Hinton et al, 2002), oxaliplatin and gemcitabine (Kollmannsberger et al, 2004), cisplatin and irinotecan (Miki et al, 2002) and cisplatin and epirubicin (Madani et al, 2003) as combinations.
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Gemcitabine has also been evaluated as single-agent therapy in multiple trials in both the first-line and refractory/resistant setting in doses ranging from 800 to 1,200 mg/m2 weekly for 3 weeks on a 28-day cycle with RRs as varied as 14.5% to 37% and OS of 21 months in the first-line setting to RRs of 20%too 37.1% and OS of 11 months in a pretreated setting [ 52, 53].
Several agents are currently being evaluated as single agents for cholangiocarcinoma including capecitabine and erlotinib [8], [9].
Three phenols, BPA, benzophenone-3, and triclosan, were each above the LOD in at least 75% of study participants and were evaluated as single compounds in our analysis.
Available experimental data of cyclically and tensile-deformed copper single crystals were evaluated as quantitatively as possible in the framework of the composite model.
Parameters of angiogenesis were evaluated as above.
30 Regorafenib has been evaluated as a single agent in two Phase I dose-escalation trials (Table 1).
Oxaliplatin has been studied in combination with raltitrexed, vinorelbine, and gemcitabine, but has not been evaluated as a single agent in this disease [ 3 ].
Bevacizumab (Avastin; Genentech/Roche) is a monoclonal antibody to circulating VEGF and has been evaluated as a single agent or in combination with various chemotherapy agents in the management of metastatic STS.
Obatoclax mesylate has been evaluated as a single agent in several independent Phase I or II clinical trials in patients with advanced, often heavily pretreated, hematological malignancies (Table 1).
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Justyna Jupowicz-Kozak
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