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HIF has been estimated to regulate more than 5% of total human genes.
Mature miRNAs have been estimated to regulate at least 60% of human protein-coding genes [15].
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Note that in the selection of the TFs, we only selected those that were estimated to regulate the genes including the expression signature, to consider the enrichment of the regulated genes in the signature.
miRNAs are estimated to regulate at least one third of all human transcripts [14].
microRNA are estimated to regulate the expression of greater than 60% of all protein-coding genes.
MicroRNAs are estimated to regulate the expression of >60% of human protein-coding genes.
Human miRNAs are estimated to regulate more than 60% of all protein-coding genes (Friedman et al. 2009).
MiRNAs are estimated to regulate the translation of well over half the transcripts in the human genome [1 3].
As a group, miRNAs are estimated to regulate 30% of genes in the human genome (Lewis et al, 2005).
Mammalian miRNAs are estimated to regulate 30% of all protein-coding genes through posttranscriptional modification (Filipowicz et al. 2008).
MicroRNAs are estimated to regulate the expression of over 30% genes and their functions [ 35, 36], suggesting a possibility that some specific microRNAs might directly regulate TP53INP1.
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been identified to regulate
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