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Through various animal models and human studies it has now been established that persistent hyperglycemia in T2DM elicits the innate immune system and chronic low grade inflammation [ 19].
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Moreover, it has been established that the persistent of infectious disease analysed by use of deterministic system becomes extinct under the same conditions due to the stochastic disturbance.
It is well established that persistent infection with high-risk (HR) human papillomavirus (HPV) is the most important cause of CC, causing the vast majority of cases [ 9].
However, it is well established that persistent inflammation can activate cancer growth [ 8, 9], and in NSCLC, a prominent role for COX-2-derived lipid mediators has been postulated in this context [ 10, 11].
It is well established that persistent infection with high-risk (HR) human papillomavirus (HPV) causes CC [ 5, 6].
It is well established that persistent infection with high-risk human papillomaviruses (HPV) plays the leading etiological role in the development of cervical and anal cancer and their immediate precursors [ 1– 3].
It has been established that the suppression of synovitis in RA may be associated with some persistent disease at the histological level [ 40].
It has been established that an association exists between wild birds, especially birds of prey, and persistent chemical pollutants in the environment [ 9].
To date, it has been established that such complex mechanism of bacterial interaction with human host can shape the successful and persistent colonization of H. pylori [ 3, 4].
The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown.
"That has not been established".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com