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It has been established that circulating maternal RNA contains placental embryonic RNA [2].
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In order to study CTCs as a biomarker in HCC, however, it is essential to establish that circulating epithelial cells in HCC populations are true tumor cells, rather than benign epithelial cells released into circulation as a consequence of the underlying inflammation or aberrant vasculature associated with liver disease.
It has been established that majority of circulating vitamin D is bound both to vitamin D binding protein and albumin [ 50, 51].
Based on experience acquired over the years and the investigative work conducted by F.C. Bond, it was established that the optimum circulating load for a closed ball mill – cyclone circuit is around 250%.
Our findings have particular relevance to AD because it is established that AD patients display elevated circulating cortisol levels [24].
Today, it is well established that circulating monocytes represent a heterogeneous cell population.
It is however, established that circulating soluble-IL-7R (sIL-7R) may have a role [ 47, 48].
"That has not been established".
That's not been established.
Proof of concept has been established for non-cellular glucose-responsive insulin delivery ('smart insulins') to release insulin from implants or circulating depots in proportion to circulating glucose.
Next, it has been established in both humans [ 8] and animals [ 15] that hemofiltration can alter the circulating concentrations of some mediators.
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