Sentence examples for been established that aberrant from inspiring English sources
As a general rule, it has been established that aberrant mRNAs containing PTC located either less than 50 55 nucleotides upstream of the last exon-exon junction or in the last exon are not degraded by NMD (NMD-irrelevant) [2].
It has been well established that aberrant overactivation of AKT1 signaling promotes tumor growth.
It has been firmly established that aberrant methylation of CpG islands in the promoter regions and in the initial exons of many genes occurs in the early stages of carcinogenesis and results in suppressed expression of a variety of genes in a diverse array of cancers (22, 23).
It is well established that aberrant epigenetic regulation observed in cancer is manifested as global changes that alter chromatin packaging and localized changes at gene promoters, which influence the transcription of genes.
And it is well established that aberrant hypermethylation of the promoter region of tumor suppressor genes is associated with transcriptional silencing, and that hypermethylation is an alternative mechanism of functional inactivation [ 9] Moreover, promoter hypermethylation of tumor-related gene has also been proposed as a novel biomarker for detecting cancer and predicting prognosis [ 10].
It is well established that aberrant cell growth (increased/dysregulated ribosome biogenesis and protein synthesis) are common features of cancer.
It is well established that aberrant editing patterns can lead to diseases such as epilepsy [ 30], depression [ 37], amyotrophic lateral sclerosis [ 38] and malignant gliomas [ 39].
It is now well established that aberrant DNA methylation processes are often a causal factor in many forms of cancer as well as several major neurological disorders (Robertson 2005).
"That has not been established".
Because aberrant methylation has been established as a ubiquitous lesion in MDS patients, hypomethylating agents have emerged at the forefront.
Recently, connection between aberrant regulation of cholesterol homeostasis and multiple types of cancer has also been established.
