Sentence examples for been established in phase from inspiring English sources

The safety profile of Treg cells has been established in phase I clinical trials [ 11, 12] demonstrating that Treg cells are a suitable candidate for therapeutic purposes.

The efficacy of docetaxel as a single agent (Nabholtz et al, 1999; Sjostrom et al, 1999; Jones et al, 2005) or in combination with cytotoxic agents (O'Shaughnessy et al, 2002; Chan et al, 2005) has been established in phase III trials in this setting.

Drug doses are established in phase I studies, but infusion length or administration frequency are commonly determined empirically based on available preclinical data.

Children's centres were established in phases, with the first phase being those in the most disadvantaged areas.

Anti-VEGF therapy with ranibizumab for the treatment of DME has been established in multiple Phase II and III studies.

The efficacy and safety of certolizumab pegol (CZP), the only PEGylated anti-TNF for the treatment of RA, has been established in several phase III clinical trials [ 13- 15].

Recent Japanese legislation will allow the commercialization of cell-based interventions once their safety has been established in in early-phase studies (Cyranoski, 2013), and a drug for the treatment of lung cancer was recently approved for use in the US after a single phase 1 study (Khozin et al., 2015).

However, once the validity and internal consistency reliability of a newly constructed test have been established in the initial construction phase, it may be worthwhile to develop shorter versions to accommodate the various reliability needs that exist in group research.

The efficacy and safety of dapagliflozin as monotherapy and as add-on/combination therapy with existing antidiabetic treatment in patients with diabetes mellitus has been established in a series of phase II and III trials in the clinical development program and is supported by five recently published comprehensive reviews or meta-analyses [ 37– 41].

The efficacy of duloxetine (40 120 mg/d) in the acute treatment of MDD has been established in a number of acute phase, double-blind, placebo-controlled studies, in addition to a long-term open-label study [ 9- 14, 35].

Treatment of the indeterminate phase has been established in children up to 12 years of age based on the positive results obtained from specific treatment by Andrade et al. [ 61] in Brazil and Sosa-Estani et al. [ 62] in Argentina.