Bacterial colonies were found to be established in brain on the very first day of sepsis induction in experimental group but no bacteria were observed in sham-operated animals.
For example, mice and human may have a distinct progression of the disease [21], (i.e., the disease could not have been established in the brain of the mice, yet), or these tissues may have been differentially exposed to ER-stress conditions.
In contrast, while a higher concentration of Al3+ has been established in AD patients' brain, the mechanism of its pathogenesis in AD is still debated.
Accordingly, disease models have been established in lung, cardiac, and brain.
The angiogenic potential of LXRs has been established in the ischemic rat brain [ 118] and following stroke [ 21].
Its clinical utility has been established in several cerebral conditions such as brain tumors, infarction, and vascular lesions [ 12– 12].
A critical role for microglial cells in clearing Aβ from the brain has been established in transgenic mice [ 3] and the results from this study also suggest efforts by microglial cells to clear soluble and insoluble fibrils.
It is during this stage of infection that virus first appears in the brain; however, it remains unclear whether HIV infection is established in the brain at this time [ 196].
These results would suggest that plasmin is important in the migration of tumor cells across the blood-brain barrier into the brain parenchyma and not in the growth of the tumor once it is established in the brain.
