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Additionally, the link between an epileptogenic phenotype and hyperactivity of the mTOR pathway has been established from studies in both human and mice28, 30, 48.
This data is used as a means of validating that the temporal clustering accurately models the expression and interactions of specific genes, since the expression of many of these genes has been established from studies of embryological and post natal endochondral bone formation.
In eudicots, floral organ identities are explained by the ABC model, which has been established from studies on two model plants, Arabidopsis thaliana and Antirrhinum majus [ 2].
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Again, both of these main pathways have been established from animal studies and the extent to which they apply to humans is still somewhat unclear.
The relationship between radon and lung cancer has mainly been established from epidemiologic studies of underground miners [ 52].
It has been established from longitudinal studies that in older individuals, diabetes is a risk factor for dementia and for cognitive decline (1, 2).
7 Yet it has been established from autopsy studies that many men dying of causes other than prostate cancer none the less harbour prostate tumours.
Important links between MAPK activities and fundamental processes like cell proliferation/differentiation and defence responses have been established from extensive studies performed in human, mouse and yeast systems [ 2].
The potential for very high Se status to produce adverse physiological effects has been established from animal studies and accidental exposure on humans; these physiological effects have produced an array of clinical indicators but few biomarkers with predictive potential.
The physiological significance of KChIPs 2 and 3 in the heart and the brain has been established from the study of mouse knockouts [ 9– 11].
The role of caspase-1 in pyroptotic cell death in sepsis has been established from a study, which identifies a number of proteins that act as the substrates for caspase-1, for example, glycolysis pathway proteins.
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