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Constitutively active mutants (CAMs) of AT1 receptor have been engineered using molecular modeling and site-directed mutagenesis approaches among which substitution of Asn111 in the transmembrane helix III with glycine or serine results in the highest basal activity of the receptor.
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The Schottky barrier height in Al/n-In0.35Ga0.65As was engineered using thin p-type near-interface In0.35Ga0.65As layers grown by molecular beam epitaxy.
Insulin analogues have been engineered to enhance desired molecular properties without altering immunogenicity.
Recently, genetic mouse models of cardiac-restricted steatosis have been engineered to unravel the molecular mechanisms of lipotoxicity.
Next, they fish out the opsin's gene and insert it into a neuron within the brain, using viruses that have been engineered to be harmless —"disposable molecular syringes," as Dr. Anderson calls them.
Split-luciferase reporters have been engineered that allow bi-molecular interactions to be studied.
Inspired by biology, DNA3 and proteins4 have been engineered to spontaneously form exquisite molecular architectures on solid surfaces.
Fifteen mutant dengue viruses were engineered and used to identify AAs in the molecular hinge of the envelope protein that are critical to viral infection.
Previously, the trypsin binding loop of EETI-II has been engineered to confer binding to several alternative molecular targets.
Nanomaterials can be engineered to serve as targeted molecular imaging contrast agents and antitumor drug delivery vehicles [ 76].
The recombinant EIAs using molecular engineered reagents are promising to be used for simple and rapid clinical diagnoses and large-scale epidemiology studies.
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