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Sertoli cells have been engineered to secrete the necessary proteins capable of restoring normal cell and metabolic function [ 45], indicating extreme promise of Sertoli cells to be exploited in cell-based therapy.
67 L. jensenii bacteria have also been engineered to secrete the anti-HIV-1 chemokine RANTES as well as C1C5 RANTES as a proof of concept for the use of L. jensenii-produced C1C5 RANTES to block HIV-1 infection of CD4+ T cells and macrophages, hence moving towards the development of a live anti-HIV-1 microbicide.
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The first system utilizes attenuated strains of Gram-negative bacteria which are engineered to secrete heterologous antigens via the α-hemolysin secretion system (type I) of Escherichia coli.
Intestinal K cells are glucose-responsive endocrine cells that might be engineered to secrete insulin.
Tumor cells can also be engineered to secrete cytokines and chemokines.
The vaccine was engineered to secrete IL-12 and IL-18 by means of the EBV/lipoplex.
HuMSC were engineered to secrete human Erythropoietin, Interleukin (IL- 3, or IL- 3 using MoruLV-based retroviral vectors.
Yersiniae can be engineered to secrete or translocate heterologous antigens into the cytosol of antigen-presenting cells by their type 3 secretion system (T3SS).
We generated an EL-4 lymphoma cell line (herein named EL-4-IL-33) that was engineered to secrete an active form of IL-33.
A CHO cell line was engineered to secrete C28-β-glucuronidase fusion protein.
Several studies indicate that liver cells can be engineered to secrete biologically active insulin [ 12- 14].
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