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These adenoviruses are replication-selective, meaning that they have been engineered to replicate only in cancer cells bearing certain mutations.
Several species have been engineered to replicate in yeast and thus serve as an excellent model system to study replication, RNA recombination, cis- and trans-replication factors, host replication factors, as well as translation.
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Viruses have many properties that can be adapted to achieve this therapeutic endpoint; furthermore, they can be engineered to replicate selectively in cancer cells and lyse them.
To achieve this, HSV-1 [10], adenovirus [17] and vaccinia virus [18] have been engineered to selectively replicate only in tumor cells.
Conditionally replicative adenoviruses (CRAd) are engineered to selectively replicate within and kill tumor cells through the use of "cancer cell -selective promoter elements that transcell -selectivestrict expromoter of gelementsenthat for CRAd replicatranscriptionally
A compelling solution is offered by oncolytic viruses (OVs), which can be engineered to selectively replicate within and destroy tumour tissue while simultaneously augmenting antitumour immunity.
Further refinements are predicted with the advent of bioprinting technologies, and newly defined biomaterials and autologous cell sources that can be engineered to more accurately replicate human skin architecture, function and cosmesis.
These viruses are engineered to carry and replicate foreign genes in susceptible host plants.
The sacB and kanR encoding vectors pSMV3 and pK18mobsacB, which are unable to replicate in G. sulfurreducens, were engineered to contain homologous regions flanking GSU0299.
CG7870 is a replication-selective oncolytic adenovirus genetically engineered to replicate preferentially in prostate tissue.
It is engineered "to lock in hydration".
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