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The suture's coating has been engineered to release its active ingredients locally during the first few days following surgery.
For example, polylactic acid scaffolds have been engineered to release recombinant BMP-2 in a sustained fashion, which was sufficient to induce a favorable chondrogenic response in vitro [ 146].
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Heteropolymer gels can be engineered to release specific molecules into or absorb molecules from a surrounding solution.
pH-sensitive drug delivery systems can be engineered to release their contents or change their physicochemical properties in response to variations in the acidity of the surroundings.
Nanocarriers can increase the bioavailability of nutrients, and be engineered to release their cargo in a manner that suits specific applications.
In addition, such cells may release, or be engineered to release, neurotrophins with subsequent paracrine recruitment of endogenous host cells to promote concomitantly a regenerative response of nerve-integrated muscle.
In addition, such cells may release, or be engineered to release, neurotrophins with subsequent paracrine recruitment of endogenous host cells to concomitantly promote a regenerative response of nerve-integrated muscle.
To study the feasibility for long-term seizure suppression by adenosine releasing brain implants, in the present contribution, mouse C2C12 myoblasts were engineered to release adenosine by genetic inactivation of adenosine kinase.
Also, natural polymers can be engineered to release growth factors and related agents in response to physiologic signals to imitate the natural healing process and to promote fast tissue regeneration and reduce scarring in wounds.
Specifically, biodegradable poly ethylene glycol -poly(lactic-co-glycol -polyd) (PEG-PLGA) microparticles were engineered to relactic-co-glycolicmycin, and IL-2, to locally sustain a microenvironment that promotes Treg differentiation.
Furthermore, some components of the ERG were augmented when hNPCctx were engineered to release GDNF.
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CEO of Professional Science Editing for Scientists @ prosciediting.com