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The (strept avidin scaffold has been engineered to extend the existing range of applications and to develop new ones.
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Here we describe the use of an amyloid-β degrading enzyme, the endogenous metallopeptidase neprilysin, which is fused to albumin to extend plasma half-life and has been engineered to confer increased amyloid-β degradation activity.
Artificial QconCAT proteins that contain multiple extended-peptides have been engineered to enable multiplexed quantification of a large number of targets.
Several protocols have been engineered to isolate DNA tethered to the nuclear scaffold/matrix away from freely extended loop DNA.
This domain consists of a 5 kDa protein that has been engineered to bind HSA with high affinity and is designed to enhance the efficacy of biopharmaceuticals by extending their circulatory half-life in patients.
The system utilizes the Escherichia coli enzymes LeuABCD, which were engineered to accept bulkier nonnatural substrates, and was able to extend the chain length iteratively.
Particular attention is given to new approaches which can extend dosage form retention time or can be engineered to deliver complex molecules such as proteins and peptides.
It is engineered "to lock in hydration".
Antibodies are privileged molecules in this regard and they have been engineered by nature to remain circulating in the bloodstream for extended periods of time (typical half-life for an IgG is around 2-3 weeks).
Using another vaccine design tool called the EpiAssembler, a new set of overlapping, conserved and immunogenic HIV-1 peptides were engineered creating extended "immunogenic consensus" sequences.
E. coli strains capable of producing heterologous 1-propanol were engineered by extending the dissimilation of succinate via propionyl-CoA.
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