Sentence examples for been engineered to develop from inspiring English sources
Icam1 is an adhesion molecule composed of repeating immunoglobulin-like domains, and several different gene disruption strategies have been engineered to develop Icam1 knockout mice including the Icam1tm1Jcgr allele which disrupts exon 4 (Ig domain 3) [ 52], the Icam1tm1Bay allele which disrupts exon 5 (Ig domain 4) [ 53], or Icam1tm1Alb allele which deletes the entire coding sequence [ 54].
New animal tests are also in the works, like mice that are being genetically engineered to develop tumors more quickly.
Differences between the two studies can be related to genotypes (hAPPswe-ind are engineered to only develop amyloid-dependent pathology while our model shows also tau-dependent pathology), drug regimen (4-week treatment by gavage at 5 mg/kg/day instead of a 9-month treatment of 20 mg/kg/day administered by food), and used TZD (ROSI instead of PIO).
Cancer comprises the single biggest group of models including syngeneic mouse/rat tumours that can either be subcutaneous or orthotopic and allow the study of anti-tumour immune response; human tumours that need to be implanted in immunosuppressed hosts; carcinogen-induced tumours; and mice that have been genetically engineered to develop cancer (often by pathways similar to those in patients).
Dr Al-Abed also investigated the drug's effectiveness on another group of mice that had been genetically engineered to develop type-1 diabetes.
Other models include hybrid models featuring the implantation of SCID mice with bone chips (SCID-hu or SCID-rab) or 3-D bone scaffolds (SCID-synth-hu), and mice that have been genetically engineered to develop myeloma.
This pathogenic mechanism, which is essentially covered by the amyloid cascade hypothesis [ 80], is founded on numerous animal models which are genetically engineered to develop amyloid plaques.
Then, they dosed old mice that were genetically engineered to develop AD-like plaques with the compound.
The first group of these models arises in mice that are genetically engineered to develop cancer.
He produced mosquitoes that were engineered to need an antibiotic, tetracycline, to develop beyond larval stage.
