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In this chapter, fundamental scaffold design variables (i.e., mass transport, mechanics, electrical conductivity, surface chemistry and topology) are decoupled and analyzed in terms of how they have been engineered to control cell behavior through different constituent biomaterials and architectural structures.
Protein photoreceptors belonging to several major classes have been engineered to control biological activities in a light-dependent manner.
An additional advantage of bacteriophytochromes over other phytochromes that have been engineered to control gene and protein activities is that their chromophore, biliverdin IXα, is naturally produced in mammalian cells as a first intermediate in the heme degradation pathway.
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Other research is exploring how RNA, for example, can be engineered to control the reading and writing of information to synthetic biological bits.
These results show that the trap density of n-type semiconducting polymers could be engineered to control the inherent charge-trapping capability and device performance for developing high-performance low-cost memory devices.
Bio-active materials consisting of lipase encapsulated within porous silica particles were engineered to control the adsorption kinetics and molecular orientation of lipase, which play critical roles in the digestion kinetics of triglycerides.
This work shows how integrin-dependant cellular interactions with the ECM can be engineered to control stem cell fate, within a system appropriate for both 3D cell culture and tissue engineering.
Second, vectors can be engineered to control the expression of the genes they carry, and so they play an important role in the expression and subsequent purification of proteins or RNA products.
Hydrogel matrices thus can be engineered to control cell behavior by providing appropriate biophysical cues initially and upon degradation.
Thus, custom zinc finger proteins can be engineered to control the expressions of target genes and have therapeutic potential for the study and treatment of diseases.
In the former, the drug is stored in one or more reservoirs located between the backing of the patch and a membrane that is engineered to control the rate of diffusion into the skin [ 1].
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CEO of Professional Science Editing for Scientists @ prosciediting.com