Sentence examples for been engineered for antigen from inspiring English sources
We present the crystal structure and biophysical characterization of a human VL [variable domain immunoglobulin (Ig) light chain] single-domain intrabody that binds to the huntingtin (Htt) protein and has been engineered for antigen recognition in the absence of its intradomain disulfide bond, otherwise conserved in the Ig fold.
Fcabs (Fc antigen binding) are crystallizable fragments of IgG where the C-terminal structural loops of the CH3 domain are engineered for antigen binding.
Fcabs contain non-CDR loops, which have been engineered for binding to an antigen (Fig. 1) [ 8, 9] and thus are promising drugs for therapeutic applications.
This study demonstrates that artificial binding sites of Fcab molecules (i.e. C-terminal structural loops in CH3 domains) can be engineered for pH-dependent antigen binding.
They can be engineered for high stability, facile antigen conjugation in precise orientations, and high potency.
The AB loop, which can be engineered for the contribution to antigen binding in an Fcab as well, is hardly affected.
Type-III protein secretion systems are being considered for vaccine development as virtually any protein antigen can be engineered for delivery by these nanomachines into the class I antigen presentation pathway to stimulate antigen-specific CD8+ T cells.
Bacillus subtilis has been engineered successfully to express heterologous antigens for use as a vaccine vehicle that can elicit mucosal and systemic immunity response.
Lactobacillus acidophilus has been engineered to express a Bacillus anthracis protective antigen fused to a dendritic cell-targeting peptide.
