Considering toxicity of external beam chemoradiation, it has to be emphasized, that severe toxicity is closely associated with the radiation technique and the irradiated volume.
It should be emphasized that the most severe form of periodontal disease (pockets ≥ 6 mm), which requires treatment and specialized dental follow-up to ensure that these pockets do not cause tooth loss, was found in Group 3 [ 47, 48].
Although most cases of severe hypercalcemia are seen in malignancy [ 14], it is important to emphasize that severe hypercalcemia with raised PTH is pathognomonic of primary hyperparathyroidism [ 16].
It should be emphasized that in patients with severe heart failure and additional severe sepsis or septic shock, skeletal muscle StO2 provides a falsely favourable impression of body perfusion.
However, it must be emphasized that patients with any more severe spinal trauma, for example, severe myelopathy (i.e. Nurick scale 4 or 5) or spinal cord injury worse than ASIA-D, kyphotic deformity, facet incompetence, inadequate integrity of the posterior element, or obvious instability, are definitely contraindicated for arthroplasty.
In addition, it should be emphasized that only presumed healthy individuals without severe comorbidity were invited to participate in the memory and intelligence test.
Although periodontal disease is more severe during adulthood, it should be emphasized that this disease is essentially progressive.
It should be emphasized that premature debonding of the CFRP laminates was not observed in these severe environmental conditions.
However, it should be emphasized that the mitochondrial defects in our mtDNA-depleted A549 system will be more severe than those found in human tumors.
It will be emphasized that if the patient gets worse during the study treatment or experiences any severe adverse effects, she must contact the study site or come back for a medical consultation.
