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Exact(8)
Using the RR, we can estimate how many mutations that create plausible NAGNAG sites have been eliminated by selection.
Using three-species comparisons, we estimate that more than half of all mutations that create NAGNAG acceptors in the coding region have been eliminated by selection.
To estimate what percentage of mutations that create plausible NAGNAG sites have been eliminated by selection, we computed (1-(1/RR))*100.
We found that the creation of an implausible NAGNAG site in the CDS is 2.6-fold more likely than the creation of a plausible NAGNAG, indicating that 62% of plausible NAGNAG creating mutations have been eliminated by selection.
SNP A/S estimates of < 1 suggest that most nucleotide substitutions have been eliminated by selection, i.e. purifying selection, whereas SNP A/S > 1 indicate that non-synonymous nucleotide substitutions have been maintained, i.e. positive selection.
As expected, many tissue-specific genes display a higher ratio of A/S SNP ratio than those ubiquitously expressed throughout the organism, i.e. fewer non-synonymous mutations have been eliminated by selection and are evolving more rapidly.
Similar(52)
If the gene is lethal even in single copy, all the genes are eliminated by selection in the same generation in which they arise, and the frequency of the gene in the population is the frequency with which it arises by mutation.
The reduced fitness of hybrid animals within the zone has been proposed to create a genetic sink, where genes entering the zone are eliminated by selection [32].
In other words, a deleterious mutation subject to negative selection such that 2Nes>10 will never go to fixation by chance through genetic drift, but will eventually be eliminated by selection.
If deletions are eliminated by selection, populations that emerge in culture should carry more amplifications than deletions.
Even when a population is in the process of adaptation, the majority of its mutations are still deleterious and will ultimately be eliminated by selection.
More suggestions(17)
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been fixed by selection
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been achieved by selection
been retained by selection
been conserved by selection
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been eliminated by outboard
been affected by selection
been altered by selection
been favoured by selection
been favored by selection
been optimized by selection
been maintained by selection
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com