Sentence examples for been earlier implicated in from inspiring English sources

Pemetrexed, which has been earlier implicated in treatment of lung cancer, also exhibited a good binding affinity (− 32.76 .The residues which played a crucial role in the formation of strong H bonds are Ser102, Gly101, Arg243, Lys360, Asn361 and Lys 237.

TbUGP contains all of the crucial amino acids that were earlier implicated in catalysis or SB of UGPs from other eukaryotic species (Chang et al. 1996; Duggleby et al. 1996; McCoy et al. 2007).

Transforming growth factor beta (TGFβ) has been earlier implicated to play a major role in tumor metastases by increasing expression of its downstream genes.

It is noteworthy that PGL has earlier been implicated in optimal mitochondrial functions and maintenance of yeast susceptibility to azole antifungals [36].

The predicted Sp1 site in the Vdac1 gene was of special interest since aberrant Sp1 mediated interaction has earlier been implicated in Huntington's disease mechanism [11].

But the prosecutors said they did not have enough evidence to charge Chechnya's leader, Ramzan A. Kadyrov, who had earlier been implicated in the crime.

Auxin related gene family has earlier been implicated in mediating auxin signaling extensively and controlling almost all the processes from embryogenesis to flowering [17].

Genes in cluster 1 were predominantly upregulated early and were implicated in cell cycle control, DNA repair, apoptosis, TGF β and Wnt signalling pathways.

Our inference that the early checkpoints are implicated in fidelity is supported by the observation that they are compromised in mutator mutants Y766A and E710A.

Moreover, this network was centered primarily on the hepatic nuclear factor 4α (HNF4a), a transcription factor that has been strongly implicated in an early-onset form of type II diabetes, maturity onset diabetes of the young [49].

Recently, cyclo-oxygenase (COX) enzymes, especially COX-2, have been causally implicated in the early changes associated with carcinogenesis in a number of tissues, among which the colorectal tract has been studied most extensively (Marnett and Dubois, 2002).