Sentence examples for been driven to high from inspiring English sources

Six years ago, as concern mounted in Washington about the escalating cost of the anti-anemia medications, researchers began to find evidence of an increased risk of cardiovascular problems in kidney patients whose blood counts had been driven to high levels by the drugs.

Second, during such bottlenecks, some (strongly) deleterious alleles may have been driven to high frequency, and now contribute to inbreeding depression.

A minority of nonsynonymous mutations may have been driven to high frequency by positive selection (which would downwardly bias our estimates), although positive selection acting on intron splice sequence mutations is also conceivable.

In some cases it is the protective allele [ 17, 53], and in others the risk allele [ 15], which appears to have been driven to high frequency by positive selection.

To test whether these alleles may have been driven to high frequency by selection at linked loci during domestication (Lu et al. 2006), we analyzed the pattern of haplotype sharing across the genome (PHS statistics; Toomajian et al. 2006).

Our model is also able to account for aspects of host demography that may confound the interpretation that TE insertion alleles have been driven to high frequency by selection rather than drift.

As adaptive genetic variants have been driven to higher frequencies by environmental factors (i.e, positive selection), SNPs showing high FST values may be considered high priority candidates for association studies for gene by environment studies.

Here we present evidence that a derived nonsynonymous substitution (370A) in EDAR, a gene involved in ectodermal development, was driven to high frequency in East Asia by positive selection prior to 10,000 years ago.

Figure 1 demonstrates that 370A has a highly unusual worldwide frequency distribution, supporting a scenario in which the 370A allele was driven to high frequency in East Asians and Native Americans by positive selection (Figure 1).

Alternatively, the short allele may be in the process of being driven to high frequency or fixation.

If different selection pressures operated in Holstein and Angus, then different derived alleles might be driven to high frequency in the two breeds.