Because these tissues are not exposed to the outer environment, their evolution may not be driven by functional differentiation but rather by the need to maintain basal functions.
In view of this, cholesterol may be considered the most "primitive" sterol, and the evolution of the specific structure of ergosterol was driven by functional requirements specific to evolving fungi.
These correlations support the supposition that the NA homologies among the sequences are driven by functional constraints of the proteins and not by the need to maintain secondary nucleic acid structure.
Sequence divergence typically displayed strong negative selection; but several features, such as asymmetric evolutionary rates, positively-selected codons and other non-neutral substitutions, suggested that divergence of some paralogs was driven by functional change.
We aligned 39 vertebrate PGRP sequences for each locus and deduced the ancestral amino acids [ 27] at all internal nodes of the phylogenetic tree, in order to estimate the presence of parallel and convergent substitutions, which may have been driven by the functional importance of sites.
In conclusion, this study demonstrates that the evolution of treatment modality and RT techniques for BOT SCC has been driven by incorporation of functional preservation, accelerated fractionation, technical advancements, and concurrent chemotherapy.
If they did occur independently in early gymnosperm and angiosperm species, it would suggest convergent evolution which may have been driven by the deletion of structural or functional elements within each MA3 domain that may have conferred an advantage to these species.
We have used a top-down evolutionary approach to identify variation in genes that is likely to be functional, and has been driven by selection.
The sequestration of carotenoids into crystals can be driven by the functional overexpression of one biosynthetic enzyme in non-green plastids not requiring a chromoplast developmental program as this does not exist in Arabidopsis.
The association with rs2516448 seems to be driven by the functional allele MICA-A5.1.
