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It has been documented in randomized controlled trials that GRT based treatment optimization leads to a higher viral load reduction than standard care alone in treatment-experienced patients [8], [10], [11].
Similar results on treatment-induced complications have been documented in randomized and retrospective studies [ 2- 4, 16].
Such evidence has been documented in randomized controlled clinical prospective trials and has lead to the inclusion of these biomarkers in therapeutic recommendation of various international guidelines (3).
The positive effect of internet-based cognitive behavioural therapy (ICBT) on depression among adults has been documented in randomized controlled trials [ 10- 14] and community populations [ 15, 16].
48, 49 The use of TIMs in vitiligo has been documented in randomized controlled trials and in several case reports and open studies.
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This phenomenon has been documented in other randomized trials in treatment-naïve patients (pregnancy was not an exclusion criteria in a meta-analysis of 6 RCTs) [ 42].
The cardioprotective effects of ω-3 fatty acids have been documented in epidemiologic and randomized controlled trials.
Similar results on treatment-related toxicities have been documented in retrospective and randomized studies [ 6, 21, 31].
The anti-leukemic effect of low-dose cytarabine has been documented in several clinical studies [ 38] including a randomized study comparing this treatment with hydroxyurea [ 40].
Once safety and effectiveness have been documented in stage IV disease, treatment modalities should be moved rapidly into randomized and non-randomized neoadjuvant trials to confirm clinical effectiveness and to elucidate pathologic and molecular responses.
Albinism has never been documented in horses.
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