This cerebellar network oscillation has also been documented in mouse models of human conditions with complex developmental cerebellar dysfunction, such as Angelman syndrome and fetal alcohol syndrome.
Appropriate patterns of the transcription factors FOXP3 and RORC were identified in Treg cells treated with exogenous cytokine immediately after culture: IL-1β reduced FOXP3 mRNA and elevated RORC transcripts, whereas IL-2 maintained high FOXP3 but inhibited RORC transcription, as has been documented in mouse T cells [ 33].
Furthermore, H5N1 virus infections in the laboratory have been documented in mice, ferrets, monkeys, pigs, and cats [23] [28].
This cycling is under the control of molecular signals, which have been documented in mice and inferred in humans from clinical observations.
Sex differences in the pressor response to angiotensin II have also been documented in mice and rats [ 94, 95].
In addition to humans, Runx2 sequence variation has also been documented in mice [ 30- 32] and domestic dogs [ 33].
Transmission time from tick to host has been documented in mice as quickly as 15 minutes (10 ).
Extrathymic CD8+ but not CD4+ lymphopoiesis has been documented in mice, which if extrapolated to humans could partially explain those differences [ 32, 33].
One possibility is that, as has been documented in mice with a dominant negative TRα1 mutation (TRα1-PV) [10], increased hepatic DIO1 levels augment T4 to T3 conversion; alternatively, reduced tissue levels of DIO3, whose expression is TRα1 regulated [31], may contribute to these abnormalities with decreased inner-ring deiodination of T4 to rT3 and T3 to T2.
Symptomatic responses to DA exposure have been documented in mice, rats, and cynomolgus monkeys (Iverson et al. 1989; Tasker et al. 1991; Tryphonas et al. 1990a, 1990b) with the most common behavioral symptoms being scratching, tremors, and seizures at varying doses of DA.
The deficiency was documented in mouse ES cells, mouse neural progenitors, and human CD34+ haematopoietic progenitors.
