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Similar long-range intercellular structures have been documented in cell cultures of different lineages [30].
The resistance to apoptotic stimuli in RCC cells has been documented in cell lines (Wu et al, 2000) and, as already discussed, is likely to extend to primary tumours.
Apart from these putative extracellular activities, RHAMM functions in centrosomal and acentrosomal spindle assembly (Maxwell et al., 2003; Groen et al., 2004) as well as in spindle orientation (Dunsch et al., 2012) have been documented in cell extracts and cultured cells.
For instance, intermediate sensitivity to IR has been documented in cell lines from AT heterozygotes using the measurement of cell survival or chromosome damage induction as end points (Chen et al, 1978; Rosin and Ochs, 1986; Shiloh et al, 1986; Scott et al, 1996; Tchirkov et al, 1997; Neubauer et al, 2002).
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Demethylation of the 5'-UTRs of some genes with a concomitant increase in mRNA expression was documented in cell lines (Fig. 2).
That ouster, too, was documented in cell-phone videos on which passengers can be heard attesting to the injustice.
In this regard, a prominent nuclear β-catenin signal was documented in cells that overexpress the integrin-linked kinase (ILK), duplicating the events associated with the mutation of APC.
Spry inhibition of RTK-mediated ERK activation and subsequent inhibition of cell proliferation, migration, and differentiation has been documented in several cell types in vivo and in vitro [33], [34], [35], [36].
The expression and activity of cPLA2 have been documented in various cell types, such as human leukocytes and murine dendritic cells (DCs) [ 13– 15].
The presence of GRPR has been documented in small cell lung cancers [3], prostate cancers [4, 5], breast cancers [6 8] and others [9].
Such coordinate regulation of multiple Trp genes has been documented in other cell types [26].
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