A bi-functional class I/II cis-abienol synthase (AbCAS) was discovered using high-throughput 454 transcriptome sequencing and metabolite profiling of balsam fir bark tissue [9].
Valuable markers for tumor diagnosis can be discovered using high-throughput screening of proteins or peptides in biological samples, in particular using mass-spectrometry techniques.
If the molecular mechanisms which contribute to these behaviors could be discovered using high-throughput laboratory quantification, targeted studies of these same processes could then assess the genetic basis of oviposition variation in nature, even if the effects of individual genetic polymorphisms was variable.
Clinically relevant novel aberrations can be discovered using high-throughput assays such as Single Nucleotide Polymorphism (SNP) arrays and next-generation sequencing, which typically provide aggregate signals of many cells at once.
A distinct approach for high-yielding synthesis of α-hydroxyphosphonates has been discovered using various catalyst and solvents.
The latter was discovered using Denaturing High Pressure Liquid Chromatography (DHPLC) while the remaining by PCR-RFLP; all were sequenced for confirmation.
However, a low concentration of sparsely distributed nano-grain clusters was discovered using a high-resolution electron backscatter diffraction scan.
In this study, a novel PAK4 inhibitor, KY-04031 (N2- 2- 1H-indol-3-yl N2- 2- 1H-indol-3-yl N2- 2- 1H-indol-3-yl N2- 2- 1H-indol-3-yl N2- 2- 1H-indol-3-yl N2- 2- 1H-indol-3-ylt screthyl -N4- 1H-indazol-5-yl -6-methoxy-1,3,5-triazine-2,4-diamine
Significantly more gene candidates will undoubtedly be discovered using a higher content, 2nd generation microarray that is currently under development.
Many of these proteins were discovered using a high-throughput approach [ 27] that opened a vast new area for tick research and helped reveal a large number of novel proteins with completely unknown function, as well as many homologous proteins.
