More common low penetrance and/or higher penetrance rare mutations remain to be discovered to explain the missing heritability in sporadic MPN and the missing excess familial risk in MPN.
Another way to envision UMI-Bio is through a short description of an idealized class activity in which a plant cell model is discovered to be inadequate to explain phenomena and an animal cellular model is introduced.
Several genetic factors have been discovered that explain individual responses to stressful events [ 28, 29, 54– 54].
In recent years, a new subset of CD4+ T-cells has been discovered that helped to explain many of the discrepancies in the classic Th1/Th2 model, and it has been termed "Th17" based on its secretion of the novel proinflammatory cytokine IL-17 [ 23].
But it goes a step farther, beyond the known and into realms that have not been discovered and explained -- yet.
Some large-effect genes have been discovered: EDA explains 78% of the variation in the number of bony plates (Colosimo et al. 2004), PitX1 explains 65% of the variation in pelvic spine length (Shapiro et al. 2004), and Kit ligand explains 56% of the variation in gill color (Miller et al. 2007).
This itself is a pattern, a pattern about patterns, or, as Mill put it, a law about laws, a law to the effect that for all sorts of events there are laws, there to be discovered, which explain those sorts of events.
Pharmacogenetics may also play a role as genetic differences between Caucasian and Japanese patients have been discovered, but this is unlikely to explain the variation in events between the United States and European populations who have similar genetic profiles.
First, by setting out to devise a classification system based primarily on biomarkers and mechanisms, the RDoC assume that mental disorders are natural kinds that stand to be discovered and explained through a value-neutral blend of genetics, imaging, and neuroscience [ 3].
Although many pivotal SNPs have been discovered, they are far less important to explaining the differences among populations, such as the differences in physical appearance, disease susceptibility [ 25], and drug responses [ 26].
