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Five additional conserved amino acid motifs (IV to VIII), positioned towards the C-terminal protein half, have been discovered by sequence alignments, 3D modelling, and site-directed mutagenesis.
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In studies on DNA methylation in rice and corn, functional genes related to stress tolerance and heterosis have been discovered by sequencing differentially-methylated fragments (Hua et al. 2005; Zhao et al. 2007).
Possible interactions between hinge residues 52 and 277, or among 53, 135, 170, 186, 265, and 276 required for hinge function were discovered by sequence analysis to identify compensatory mutations.
The number of SNPs to be discovered by sequencing additional strains was estimated as described64.
EBV microRNAs (miRNAs) were discovered by sequencing libraries of small RNAs generated from several EBV-positive cell lines.
As new disease genes are discovered by sequencing hundreds of thousands of people, a swelling population will undergo specific panels of tests of 15 genes or more.
Additional SNPs were discovered by sequencing the transcriptomes of T. aestivum cv.
Reassortment events such as this can only be discovered by sequencing multiple virus segments.
Another element, IS _map02, is a MAP specific insertion sequence that was discovered by sequencing the K-10 genome.
The SNPs were discovered by sequencing 2 973 amplicons in a development set of 30 diverse maize inbreds.
Therefore, the entire gene pool can be fully sampled by sequencing a small set of representative isolates, and the number of new genes to be discovered by sequencing additional genomes will quickly approach zero.
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