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Another factor for proteomics is that it is of relatively low throughput compared to other omics technologies in all three phases of discovery, verification and validation and, therefore, fewer biomarkers have been discovered and validated in proteomics.
Notably, the interconnection between DSt and volume chambers serially passed by an indicator has been discovered and validated by Newman and co-workers in an in vitro model circulation rather than the human heart.
Further, novel indels have been discovered and validated from cancer samples that will be described more completely in another publication.
Many genetic susceptibility risk alleles have been discovered and validated (Stahl et al., 2010) but are insufficient to explain disease incidence.
Recently, five thyroid cancer significantly associated genetic variants (rs965513, rs944289, rs116909374, rs966423, and rs2439302) have been discovered and validated in two independent GWAS and numerous case control studies, which were conducted in different populations.
Because of the low LD in P. tomentosa, once a marker trait association has been discovered and validated, it is likely that such a marker is located in close proximity to the causal polymorphisms or even the functional variant itself (Neale and Kremer 2011).
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Whereas the sensitivity and specificity of EGFR are insufficient for a clinically useful early detection biomarker, this study suggests that proteins that are elevated preclinically in women who go on to develop breast cancer can be discovered and validated using current proteomic technologies.
Significant associations of four SNPs and haplotypes in three genes (MARCO, TNFAIP3 and CXCL12) with AR were discovered and validated, of which two in TNFAIP3 and CXCL12 were also significantly associated with immunity (fourfold increase in vibriocidal titers).
A total of 2 millions SNPs (1,751,176 anchored and the remaining present in other assembled sequences) were discovered and validated and more than a million in/dels were annotated on the sequence with defined location.
Demonstrate understanding of the process of scientific inquiry, and explain how scientific knowledge is discovered and validated.
SNPs were discovered and validated using diverse cultivated carrots, wild carrots and other wild D. carota subspecies.
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