Sentence examples for been directly implicated as from inspiring English sources
To our knowledge, oncogenic Ras has not previously been directly implicated as cooperating with aPKC in depolarized morphology in mammalian cells.
ROS have also been directly implicated as second messengers in the activation of NF- κB, based on the ability to activate NF- κB by oxidation of a cysteine-SH group or by ubiquitination and proteolysis of I κB.
The variety of animals to which exposure conferred risk, including some which have never been directly implicated as a source of STEC infections, suggests widespread contamination of farm environments.
11 12 SULF2 has been directly implicated as a driver of carcinogenesis in pancreatic cancer 13, murine and human glioblastoma 14, hepatocellular carcinoma 15 and non-small cell lung cancer 16.
Several Epc-N-containing proteins have been directly implicated as components of HAT complexes (e.g., NuA4 and TIP60 HATs2andATs aNuA3uA3 HATHAT), but intriguingly all proteins studied with PZPMs are associated with histone methylation and gene silencing.
DRA-DRB1*0301 (DR3) and -DRB1*0401 (DR4) are directly implicated as susceptibility molecules [ 7].
ApoAI is directly implicated as an important amyloid component of atherosclerotic plaques, however, whether ApoCIII plays a direct role in the formation of these plaques is unknown.
For example, p53 has been directly implicated in neurogenesis as well as in neural stem cell self-renewal, neurite outgrowth and axonal regeneration (reviewed in [ 5]), and acetylation of p53 is required for the induction of neurite outgrowth [ 6].
The miRNA expression levels in tumors can be up- or downregulated compared to normal tissue, and several miRNAs have been directly implicated in tumorigenesis by acting either as "oncomirs" or tumor suppressor miRNAs [ 15, 60, 61].
In particular, thyroid-stimulating hormone has been shown to participate in zebrafish pigment cell development but has not, as yet, been directly implicated in melanocyte development in other vertebrates.
Overexpression of the ATP binding cassette transporters such as ABCB1 (MDR1) has been directly implicated in resistance to a broad spectrum of chemotherapeutic agents in vitro including anthracyclines, paclitaxel, and the Vinca alkaloids [25], [26], [27].
