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Here, experiments have been directed toward determining the roles of the N-terminal sequence motifs both in enzymatic properties of insect DHODH produced in vitro and the in vivo function of the protein.
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Future work will be directed toward determining the appropriate background levels for inorganic materials.
Subsequent research was directed toward determining corresponding molecular mechanisms and, accordingly, numerous mechanistic scenarios were proposed and subsequently tested.
Future studies will also need to be directed toward determining if a senescence-like state can develop in terminally differentiated cells.
Diagnostic efforts should be directed toward determining whether the problem is secondary to inadequate intake, insufficient absorption, or excessive calorie requirement.
Further functional characterization will be directed toward determining the effects of the variable AAR encoded by tri-nt SSRs on the corresponding gene functions and their ecological implication.
Therefore, future experiments will be directed toward determining the mechanisms that mediate cabazitaxel resistance by various methods, such as measuring the cellular retention of cabazitaxel in cell lines that are positive and negative for ABC transporters.
Future efforts must be directed toward determining TC and BP cut-points for CAD risk stratification specifically among patients with SLE and the role of treatment of risk factors in reducing the incidence of CAD events.
Ongoing work is directed toward determining the biochemistry underlying the allele-specific accumulation of blood lead, and toward determining the contribution of human ALAD genotype to lead accumulation in other tissues in transgenic mouse models and to final lead deposition in bone in both mouse and man.
Further studies should be directed toward determining whether the alterations in histone modifications induced by exposure to Ni identified in the present study are associated with risk of cancer, as well as identifying changes in gene expression and biochemical pathways affected as a result of exposure to Ni compounds.
However, little effort has been directed toward providing sufficient content to determine precisely how an observation was made.
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