Sentence examples for been difficult to underpin from inspiring English sources

The functional interplay between chromatin modifiers, hPTMs and transcriptional outputs has been difficult to underpin because this relationship is development- and locus-dependent [ 3, 10, 38, 39]).

However, it can be difficult to understand the mathematical reasoning underpinning this calculation, because Eshelby's operation is entirely conceptual and assumes specific processes for the stress-free volume change, such as phase transition.

In the absence of physiological studies it is difficult to challenge these viewpoints, which underpin the scientific rationale advanced for the current WHO fluid resuscitation guidelines.

Health system arrangements are difficult to change and typically the rationale underpinning a change would need to be more compelling than only the possibility that it would enhance the impact of a single option.

In most cases, however, it was difficult to discern any research evidence base underpinning such statements and therefore difficult to assess the extent to which a particular policy was aligned with the goals of the National Programme.

Such an approach can help to identify specific biological processes underpinning traits that may otherwise be difficult to study in humans.

Secondly, if the theoretical premises underpinning the intervention are uncertain, intervention fidelity is difficult to monitor and maintain.

The TMT-B condition has shown impairments in many clinical populations, particularly schizophrenia patients, but the neurobiological underpinning of the task can be difficult to discern given pragmatic obstacles in adapting the task for neuroimaging.

Success of international development projects is difficult to measure, yet it is essential that some measurement underpins the justification for funding such projects.

Summary: Genome evolution underpins all of biology, yet its principles can be difficult to communicate to the non-specialist.

To be fair, it may be difficult to see the bigger picture when you are lucky enough to run a business underpinned by sovereign wealth.