Sentence examples for been difficult to rigorously from inspiring English sources

It has been difficult to rigorously determine whether RIC allo-HCT is the optimal treatment for advanced hematological diseases, due to a lack of large randomized trials.

Due to the limited availability of biomarkers of aging, it has been difficult to rigorously test whether DS is associated with accelerated aging effects, per se, versus specific vulnerabilities to conditions typically associated with old age (e.g., increased risk for Alzheimer's disease).

Until recently, it was difficult to rigorously test these hypotheses.

Moreover, it is difficult to rigorously prove the convergence of the proposed alternating algorithm for problem (7).

However, given the unclear signaling mechanisms whereby CXCR7 mediates those effects, it is difficult to rigorously define the role for that receptor in apoptosis and tumorigenesis.

Although it is difficult to rigorously benchmark the accuracy of genome annotation, our manual analysis of selected genomes indicated high quality annotation of UniFam.

While the current approach demonstrated the survival of graft cells, it is difficult to rigorously quantify the percentage of grafted cells surviving.

It is difficult to rigorously characterize differences, if any, in ventricular dysfunction between T1DM and T2DM since age and co-morbidities in study subjects are not comparable between the studies on T2DM and those on T1DM.

Rigorously controlled trials for prostate cancer have been difficult to do "because everyone felt they knew the answer," said Dr. Wasson, of Dartmouth.

This hypothesis is difficult to evaluate rigorously.

Because TBI in humans is diagnosed based on symptoms rather than by any precise medical test, and because flies subjected to mechanical impact injury by our HIT device do not exclusively contact the vial wall with their head, it is difficult to prove rigorously that we have caused a TBI-like injury in flies.