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Because the closely related L. corrugis has overlapping morphological characters, including similar colouration in the cap and stem, it has been difficult to reliably distinguish between the two species.
While morphometric analysis of renal biopsy samples can demonstrate an inflammatory infiltrate in most advanced DN samples, it has been difficult to reliably characterize inflammatory features at the transcriptomic level suggesting insufficient resolution or sensitivity of oligonucleotide microarrays or of the data analysis.
However, despite success in the past, most pharmaceutical companies have abandoned natural product drug discovery efforts over the last decade because it has been difficult to reliably access a sufficient supply of these compounds.
Enemy Creep: If you think it's been difficult to reliably distinguish enemies from the rest of us in the war on terror (as in the 600 Guantanamo detainees that the Bush administration finally declared "no longer enemy combatants" and sent home), try figuring it out in cyber space.
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Even under a Bayesian framework with which updating of the parameter values is naturally implemented, it may be difficult to reliably estimate dynamic ranks of players due to relative paucity of data.
However, when the input SNR is low, as evident in Figure 2c,d, it is difficult to reliably obtain chirp parameters corresponding to each bistatic link.
Due to individual variation, it can be difficult to reliably separate P. c. abietinus and P. c. collybita outside their main breeding and wintering ranges.
Due to the size and consistency of the embryo, it is difficult to reliably isolate sufficient amounts of lung tissue and separate the heart-lung block.
Experience has shown that it is difficult to reliably detect the two other anti-R5 HIV-1 β-chemokines, CCL3 and CCL5 by intracellular staining.
However, the RSE for the random effect correlation is very high, implying that the correlation is difficult to reliably estimate.
It is difficult to reliably estimate many parameters, and correctly infer associations from multiple hypotheses tested simultaneously.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com