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As a result it has been difficult to rationalize continued use of albumin without further evidence.
It has been difficult to rationalize the conservation of minor introns and the minor spliceosome on the basis of splicing alone, as with slight sequence variation this function could have simply been relegated to the major spliceosome.
However, previous data suggested that minor introns are generally poorly spliced, and therefore the purpose of the minor splicing pathway has been a long-standing mystery, as it has been difficult to rationalize their remarkable conservation and function in splicing alone.
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"So it's difficult to rationalize how we are still so fixated on it". Vipin Narang, a nuclear nonproliferation specialist at MIT, agreed.
A private library of good size is an insolent form of riches, and the desire to have more books is difficult to rationalize, especially in view of the fact that you do not or cannot read them all but, as Bonnet makes clear, still you might.
It is difficult to rationalize why reengaging such a polarizing figure would be a good idea.
Because large κ values, and 4 already is large, are difficult to rationalize, this again suggest that Δ is in the 100-nm range.
Finally but importantly, individuals whose behavior is difficult to rationalize tend to obtain low scores on numeracy and financial literacy questions and are less educated.
"I become a blubbering mess and I am difficult to rationalize with, even though logically I can see something is very, very tiny," she admits.
This effect is difficult to rationalize because it occurs independent of molecular shape in both planar (e.g. 6 and 7) and spherical (e.g. 5 and 8) molecules.
Catalytic promiscuity of bacterial P450s, at least CYP102A1, seems to be intrinsic to P450s, although the mechanisms by which the mutations contribute to the new activity are difficult to rationalize.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com