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First, many of these drugs have been difficult to isolate in large quantities from their biological sources and have been challenging to synthesize.
Tumours shed small amounts of cancer cells into the bloodstream, but it has been difficult to isolate and grow these cells.
But it has been difficult to isolate large numbers of these cells from the mix of tissue types that can develop from embryonic stem cells.
Homology modeling was critical for this project because, as a large transmembrane protein, ScPma1p has been difficult to isolate and crystallize.
The zygote/ookinete stages of P. falciparum are diploid and P. falciparum ookinetes have been difficult to isolate in large numbers.
However due to the non-specificity of these interventions, it has been difficult to isolate the component that initiates the reinforcing behavior, which may eventually lead to addiction.
Similar(44)
Moreover, it is difficult to isolate intact organelles, and leakage of matrix proteins during the isolation procedure is invariably observed.
It also could be difficult to isolate from the solvent.
Such systems, however, can be difficult to isolate and to access via microscopy.
It's difficult to isolate specific reasons for increased or decreased turnout.
Microorganisms, by definition, are tiny, and as such are difficult to isolate, grow and study.
More suggestions(18)
been difficult to pinpoint
been difficult to remove
been difficult to identify
been difficult to locate
been difficult to separate
been difficult to dissociate
been difficult to put
been difficult to pick
been difficult to prove
been difficult to communicate
been difficult to persevere
been able to isolate
been difficult to work
been difficult to account
been difficult to prettify
been difficult to endure
been difficult to confirm
been nice to isolate
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