This algorithm, however, is difficult to implement, and no implementation is readily available for experiments.
The M-S functional has been extensively used in image segmentation [4 7]; however, the numerical method for solving the model is difficult to implement when direct implementations are performed.
Up until now these models have been difficult to employ because their implementations did not permit the modeling of uncertainty in (1) the phylogenetic tree topology or (2) the phylogenetic positions of the rate changes between the local clock regions.
Although the last edition of the document was in 2009, it has been difficult to assess the degree of its implementation and use.
Without understanding the potential associations in this area it is difficult to plan implementation of various health-related interventions.
It is difficult to assess implementation of these guidelines but the Indonesian Society of Endocrinology has adopted an intense dissemination strategy by promoting the use of the guidelines through symposiums, workshops and training schemes.
Because building complex interactivity on the web is difficult, to speed implementation of Web Groups, we introduced two new layers to the Pathway Tools software infrastructure stack: AllegroServe, a commercially provided Lisp-based web server that replaced the previous web server CWEST (19), and WuWei (20), a toolkit for building complex Ajax applications using Lisp continuations.
"It is difficult to assess whether implementation of reform is being done in a timely manner," says Dr Jureidini.
Since the Romanian cities SUMPs are still under preparation, it is difficult to assess their implementation monitoring mechanisms and the procedures for future improvements.
The exemption policies of the 2000s have significantly improved access to care, but they are difficult to sustain, their implementation is chaotic, their funding is inadequate for the needs, and they have not yet managed to reduce the inequities of access to the healthcare system.
