β-carotene was used as a poorly water-soluble model substance that is difficult to formulate with conventional solid dispersion formulations.
Intelligibility varies so much with the speaker and the hearer, however, that it is difficult to formulate firm criteria on that basis.
It did not take Arthur long to discover that it is difficult to formulate a useful model in conventional mathematical terms.
Most invitees understand that guest lists are difficult to formulate, and that budgets, venues and large families can force tough choices.
It is difficult to formulate a distinct definition for each of these terms, because their use largely overlaps in the literature despite individual preferences.
But it is difficult to formulate the reductionist claim precisely.
It is difficult to formulate this point precisely, however.
Therefore, it is difficult to formulate adequate conclusions [2].
Owning to the different train and coupler types, it is difficult to formulate uniform regulations for train to train rescue.
Without support from top management, it will be difficult to formulate and implement market orientation and corporate social responsibility programmes.
