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Because it has been difficult to differentiate between benign and malignant insulinomas on the basis of histologic findings, malignant insulinomas have been diagnosed based on metastasis to liver, lymph nodes, or other organs [2].
Since invasive ductal carcinomas exhibit a large number of alterations, it has been difficult to differentiate between pathogenic mutations and non-specific mutations due to genomic instability.
Mechanistically, it has been difficult to differentiate between the impact of the exonuclease and helicase activities of WRN in vivo since RNAi ablates all activities, while point mutants may act as dominant negatives (Crabbe et al., 2004).
Traditional RT PCR techniques are at best semi-quantitative, and it has been difficult to differentiate between baseline levels of gene expression in normal tissues and increased levels of gene expression associated with breast cancer, raising the concern for false positive results.
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But as her daughters frequently are in the same role, it is difficult to differentiate between them.
"It is difficult to differentiate between a church and any other place that is set up for entertainment, or what they call in their language, 'fun,' " he wrote.
But it can sometimes be difficult to differentiate between a militant act, street art, vandalism and madness.
A few weeks earlier, he had undergone a stress test — "It's difficult to differentiate chest pain from anxiety from chest pain from angina".
LCH can be difficult to differentiate from multifocal osteomyelitis.
Morphologically and serologically, the two parasites are difficult to differentiate.
A stricture resulting from CD can be difficult to differentiate from an obstructing neoplasm [36].
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